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| However, people with many SNPs may have a nearly 30% higher risk of developing breast cancer and 50% higher risk of prostate cancer. Targeting screening tests to those most at risk of developing cancer Co-author, Professor Doug Easton, from the Centre for Cancer Genetic Epidemiology at the Department of Public Health and Primary Care and the Department of Oncology at the University of Cambridge, said: We're on the verge of being able to use our knowledge of these genetic variations to develop tests that could complement breast cancer screening and take us a step closer to having an effective prostate cancer screening program. By looking for people who carry most of these variations we will be able to identify those who are at the greatest risk of getting these cancers and then targeting screening tests to these individuals. Many of the SNPs the scientists discovered were located near areas of the genome that control gene behavior.
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When these control areas are altered, the brakes that prevent cells from growing out of control stop working, resulting in metastasis (cancer spreading throughout the body) or out-of-control cancer cell growth. The more we understand how these genes affect the emergence and progression of cancer, the more effective treatments and prevention programs will become. Professor Paul Pharoah, from the Centre for Cancer Genetic Epidemiology at the Department of Public Health and Primary Care, the Cambridge Institute of Public Health (CIPH) and the Department of Oncology at the University of Cambridge, said: The identification of genetic variants that are associated with cancer risks will give us important insights into the basic biology of cancer that may lead to the development of new therapies or better ways to target existing therapies. SNPs linked to Prostate, Breast and Ovarian Cancers Prostate cancer - the scientists found 23 genetic variations associated with prostate cancer, bringing the total to 78. Sixteen of these variations are specifically linked to the more aggressive and fatal forms of the disease. This groundbreaking research potentially brings us a step closer to the development of saliva tests to assess cancer risk. Scientists at the Institute of Cancer Research, London, explained that following these discoveries, it is now possible to identify the top 1% of males with the greatest risk of developing prostate cancer - these men are 4.
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